To determine whether this pathway was critical during in vitro viral infection of CPEpic-L and primary astrocytes, we supplemented teriflunomide-treated cells with 150 μM and 300 μM uridine or with 100 μM and 250 μM orotic acid, a metabolic intermediate downstream of dihydroorotate dehydrogenase. This evidence concerns the gene DHODH and viral infectious disease.