CD8A and neoplasm: In some studies, an increase in the density of T lymphocytes, regulatory T cells, and macrophages during tumor progression was observed [4,14,16], while in others, a decrease in cytotoxic CD8+ T cell counts from adenomatous lesions to ADCs [17,18], as well as a lower expression of Th1 cytokines and a shift to a Th2 cytokine profile, have been reported [4,15].