In the present study, we aimed to characterize the population of tumor-infiltrating immune cells (CD3+, CD4+, CD8+, Foxp3+, and CD57+) along the ACS, and to uncover potential differences between adenomatous and invasive lesions in the sporadic setting versus the hereditary (FAP-related) context. This evidence concerns the gene CD8A and Familial adenomatous polyposis.