AKT1 and cancer: The interaction between chemokine receptors expressed by cancer cells and their respective ligands secreted by tumor-associated fibroblasts, tumor cells and TME-infiltrating immune cells [63,64] can directly activate signalling pathways like Phosphoinositide 3-kinase (PI3K)/AKT and extracellular signal-regulated protein kinases 1 and 2 (ERK 1/2), leading to cancer cell proliferation [16,65,66].