Unlike insulin resistance in metabolic disorders, which develops over the course of months or even years, in severely burned patients, this newly acquired condition has a fast onset, representing an acute complication, caused by the activation of several signaling pathways that impair insulin receptors through a high level of stress hormones, overproduction of pro-inflammatory cytokines, or mitochondrial oxidative stress [6,10,22]. Here, INSR is linked to Insulin resistance.