Thus, the improved PDT CRC treatment outcomes produced by the final BNC was attributed to the fact that it actively and specifically enhanced the uptake of ZnPcS4 PS through direct anti-GCC mAb targeting and, with AuNP photothermal induction, was able to trigger the most significant forms of late apoptotic cell death in CRC [15]. Here, GUCY2C is linked to colorectal carcinoma.