CNR1 and memory impairment: In an in vivo model of transient global ischemia, Mori and colleagues investigated the ability of CBD to prevented anxiety-like behavior, memory impairments, and despair-like behaviors; in particular, the anxiolytic-like effects of CBD in global ischemia were attenuated by CB1, CB2, 5-HT1A, and PPARγ receptor agonists [47].