NFKB1 and acute respiratory distress syndrome: In this study, we supplemented the knowledge that DHL possesses the abilities to block the Gram-positive bacteria-mediated p38 MAPK/NF-κB pathway and to promote macrophages to switch from the M1 phenotype to M2 phenotype in RAW264.7 macrophages and primary BMDMs in vitro, as well as in a mouse MRSA-ALI model.