To conclude, the signature consisting of 32 genes whose methylation levels were reported here to be strongly and significantly correlated with expression changes could be a putative target for the development of novel epigenetic-based therapies and are worthy of further investigations to better understand the molecular mechanisms underlining the dismal prognosis of ALL infants with KMT2A/AFF1 fusions. Here, AFF1 is linked to acute lymphoblastic leukemia.