MAPT and frontotemporal dementia: Zhu et al. (2020) have not observed variations in Tau pathology after microglial depletion or engraftment of peripherally-derived macrophages [66], but the hTAU model used is less aggressive than most transgenic murine models which express the mutant Tau form associated with frontotemporal dementia: JNPL3 [110,111], PS19 [112] or rTg4510 [113].