Studies indicate that melanoma cells with an increased expression of Wnt5a induce an instantaneous extrication of exosomes that contain immunomodulatory cytokines IL-6 and pro-angiogenic factors IL-8, matrix metallopeptidase 2 (MMP2), and vascular endothelial growth factor (VEGF) in their cargo [68]. The gene discussed is MMP2; the disease is melanoma.