The protein set, consisting of tyrosinase-related protein-2 (TYRP-2), very late antigen-4 (VLA-4), heat shock protein 70 (HSP70), heat shock protein 90 (HSP90), and MET oncoprotein, was termed as an exosome-specific melanoma signature and found to be increased in stage IV patients, affecting survival and metastatic spread [62]. The gene discussed is DCT; the disease is melanoma.