In PANC-1 pancreatic cancer cells, miR-125a activated mitochondrial fission by targeting mitofusin 2 (Mfn2)—a protein localized in the outer mitochondrial membrane required for mitochondrial fusion—thereby triggering mitochondria-mediated apoptosis and impairing cancer cell invasion [83]. This evidence concerns the gene MFN2 and familial pancreatic carcinoma.