DKK1 and stroke disorder: The above-mentioned observations in NSPCs may seem to contrast with the previously described notion about the increased expression of Dkk1 protein in stroke; however, Wnt signaling may affect terminally differentiated neurons and dividing NSPCs in the neurogenic niches differently, and an insult in the form of ischemic injury may be sufficient to awaken the dormant or quiescent multipotent cells residing in the adult brain.