Considering that glucose transporters (GLUT family of transporters) can be upregulated by HIF-1 and that hypoxic cancer cells have increased GLUT expression and a 10- to 100-fold increase in glucose levels, we speculate that GLUT expression and glucose abundance may also be upregulated in highly proliferated trophoblast cells in early pregnancy [43,53,56]. Here, SLC2A1 is linked to cancer.