Indeed, immune system abnormalities associated with conditions involving augmented iron load (thalassemia, hemochromatosis) are characterized by diminished phagocytosis by the monocyte–macrophage system, changes in T-lymphocyte subsets (reflected by the increase in CD8 and the suppression of CD4), compromised immunoglobulin secretion, as well as hampering of the complement system function [7,78]. The gene discussed is CD8A; the disease is thalassemia.