The relative risk of renal damage in patients with AH is lower than other cardiovascular complications; however, researchers demonstrated that MMP-2 and MMP-9 could be involved in abnormal tissue remodeling associated with AH in renal disease by pathogenic remodeling of ECM, leading to the nephrosclerosis and, finally, to the chronic kidney disease (CKD) [21]. This evidence concerns the gene MMP2 and chronic kidney disease.