In mice, this pathway inhibits Sirt1 silencing mediated by miR-34a and promotes the stability of Sirt1 mRNA during myogenic differentiation [39]; furthermore, it attenuates pulmonary fibrosis, enhancing the stability of Sirt1 and increasing its expression during the epithelial-mesenchymal transition [63]. Here, SIRT1 is linked to pulmonary fibrosis.