This study suggested that 14,15-EET can reduce the production of reactive oxygen species induced by cerebral ischemia and reperfusion via upregulation of the expression of antioxidant genes such as HO-1, GSH-Px and SOD, thereby inhibiting the activation of PARP-1 and nuclear translocation of AIF and alleviating parthanatos of neurons (see illustration in Figure 8). Here, HMOX1 is linked to brain ischemia.