The distribution of estrogen receptors in the brain aligns with subcortical structures involved in schizophrenia (the hippocampus, amygdala, thalamus, and nucleus accumbens) and with neurotransmitter pathways (dopaminergic, serotonergic, and glutamatergic) that are implicated in the neurobiology of this disorder [43]. The gene discussed is ESR1; the disease is schizophrenia.