IPP and neuroblastoma: αβ-T cells and endogenous γδ-T cells did not show consistent activation upon exposure to neuroblastoma organoids (Figure 2): αβ-T cells did not produce IFNγ in any of the tested conditions, while endogenous γδ-T cell activation was detected only in co-cultures with AMC691T at high effector-target (E:T) ratios however, only in the presence of pamidronate that induces accumulation of IPP, which can lead to the conformational change of CD277.