When patients previously exposed to anti-PD-1 or PD-L1 antibodies (assuming these are PD-1-positive individuals) were excluded, PD-L1 expression of 25% or more on tumor cells occurred in 22.3% of patients, and the mean HR value of PFS in non-smokers was much lower than that of smokers [42]. The gene discussed is CD274; the disease is neoplasm.