KDM1A and melanoma: This is in accordance with their findings highlighting that benign naevi displayed increased senescence-associated H3K9me3 levels, with almost no detectable activity of H3 lysine 9 demethylases LSD1 and Jumonji Domain-Containing Protein 2D (JMJD2C/KDM4C), whilst human melanoma tissues generally harbored increased expression of LSD1 and JMJD2C and reduced H3K9me3 reactivity [75].