Later on, Kampilafkos at al. observed that H3K4me2 and H3K27me3 levels were lower in metastatic compared to primary melanomas and that combined IHC analysis of H3K4me2, H3K27me3, and EZH2 may help identify cancer cells with stem cell-like behaviors, particularly at the invasion front of CM [72]. Here, EZH2 is linked to melanoma.