SYK and cutaneous melanoma: On the contrary, the SYK gene was downregulated in bladder urothelial carcinoma (BLCA), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), prostate adenocarcinoma (PRAD), cutaneous skin melanoma (SKCM), and thyroid carcinoma (THCA) (Figure 1b).