SYK and cancer: The mRNA expression patterns of the SYK gene across different types of cancer samples, particularly in CRC samples, with their analogous normal control, were upregulated in BRCA, CESC, CHOL, ESCA, GBM, HNSC, LAML, READ, STAD, and UCEC, and downregulated in BLCA, KIRC, KIRP, PRAD, SKCM, THCA, etc. (Figure 1).