The main objective of the study was the assessment of motor impairment (MDS-UPDRS), cognitive impairment (MoCA), olfactory dysfunction (UPSIT), autonomic impairment, depression, and anxiety. 65 patients underwent DAT-SPECT.RBD with abnormal DAT-SPECT had a higher MDS-UPDRS motor score and higher prevalence of orthostatic hypotensionPutaminal binding ratio positively and negatively associated, respectively, with UPSIT score and tonic and phasic muscle activity during REM sleep. Here, SLC6A3 is linked to major depressive disorder.