Active periodontal disease cases demonstrated significantly elevated absolute turnover of PepA BOTHi (p = 0.028 *), PepC (p = 0.035 *, ES 0.75) and PepC MMPi (p = 0.011 *, ES 0.92), PepB total activity (p = 0.025 *) as well as for PepB COMi (p = 0.044 *, ES 0.69), however, this did not affect relative levels or any feature of the biopsy material. This evidence concerns the gene CNDP2 and periodontal disorder.