A positive substance abuse status (n = 9), correlated with an increased degree of MMPi inhibition attained for PepA (p = 0.02 *, ES 0.7), PepC MMP/CSC ratio (p = 0.015 *, ES 0.95) and PepE CSC inhibition (p = 0.01 **, ES 0.9), PepB BOTHi inhibitions for dual inhibition were altered in salivary and biopsy specimen (S: p = 0.038 *, ES 0.8; C: p = 0.013 *, ES 1.7). Here, CNDP2 is linked to substance abuse.