SCUBE2 and breast neoplasm: SCUBE2 (signal peptide, CUB domain, and EGF-like domain-containing 2) encodes a secreted, membrane-associated multidomain protein, which was reported as a breast tumor suppressor [39] and is included in both MammaPrint® and Oncotype DX®, which are widely used diagnostic molecular tests to predict the risk of recurrence [40].