The group of Hirokazu Matsumoto found that the siRNA-conjugated anti-CD71 Fab’ fragment resulted in efficient gene silencing in the liver, heart and calf muscles in healthy mice after intravenous administration, and the silencing of myostatin in a peripheral artery disease (PAD) model of mice with femoral artery ligation led to the recovery of leg functions [80]. This evidence concerns the gene MSTN and peripheral arterial disease.