EGFR and neoplasm: The IC50 values of TQB3804 for ex19del//T790M/C797S, L858/T790M/C797S, ex19del//T790M and L858/T790M mutations were 0.46, 0.13, 0.26, and 0.19 nm, respectively, suggesting a good inhibitory effect on tumor cells with triple and double EGFR mutations after first-, second-, and third-generation TKI resistance [124].