Nevertheless, some EGFR-dependent ARMs, such as the EGFR C797S mutation, seem to be targetable with new fourth-generation EGFR TKIs in preclinical studies (e.g., BLU-945 [9,10] and EAI045 [11]) and a clinical trial is currently evaluating the efficacy and safety of one of them (BLU-945) in EGFR-mutant NSCLC (Supplementary Table S2). This evidence concerns the gene EGFR and non-small cell lung carcinoma.