Preclinical and clinical data from case reports suggest that the targeted therapy approach using the triple EGFR/BRAF/MEK pathway co-inhibition may be effective and well tolerated in patients with EGFR-mutant NSCLC and BRAF activation as an ARM to EGFR TKIs [25,26,27,29,30,42]. This evidence concerns the gene BRAF and non-small cell lung carcinoma.