Furthermore, the combination of the BRAF kinase inhibitor dabrafenib with the MEK kinase inhibitor trametinib is approved by the U.S Food and Drug Administration, as well as the European Medicines Agency, in the first-line setting of advanced-stage NSCLC harboring a BRAF V600E mutation based on a phase 2 trial which showed an objective response rate (ORR) of 64%, a median duration of response of 15.2 months and a median PFS of 14.6 months, if assessed by the independent review committee, or 10.9 months, if investigator-assessed [36] (Supplementary Table S1). Here, BRAF is linked to non-small cell lung carcinoma.