It shows an efficacy equal to or better than PDT combined with photo-thermal therapy (PTT) and TLR9-agonist CpG [66], PDT combined with CpG and a hypoxia inducible factor (HIF) inhibitor [65], CD276-targeted PDT combined with immune checkpoint inhibitors [68], and PDT with magnetic hyperthermia and immune checkpoint inhibitors [69]; all show a tumor growth inhibition at early timepoints after treatment but do not show long term survival (up to 50 days). This evidence concerns the gene TLR9 and neoplasm.