NRP1 and central nervous system cancer: Interestingly, tLyP-1, a tumor-homing peptide, which contains a C-end Rule sequence that can facilitate tissue penetration via the neuropilin-1-dependent uptake pathway, was coadministrated with lactoferrin-functionalized NPs to augment its accumulation and deep penetration into the glioma parenchyma, suggesting its suitability for antiglioma drug delivery [111].