Interestingly, tLyP-1, a tumor-homing peptide, which contains a C-end Rule sequence that can facilitate tissue penetration via the neuropilin-1-dependent uptake pathway, was coadministrated with lactoferrin-functionalized NPs to augment its accumulation and deep penetration into the glioma parenchyma, suggesting its suitability for antiglioma drug delivery [111]. The gene discussed is NRP1; the disease is glioma.