LCP siControl+PDT, LCP siEGFR+LCP-Pyro PA without light, and LCP siEGFR+PBS+light groups demonstrated significant inhibition (p < 0.01) in Ki67 amounts compared to PBS group for SCC4 and SAS xenograft models, revealing that LCP-Pyro PA–mediated PDT alone or siEGFR-loaded LCP NPs alone contributed significantly decreasing tumor cell proliferation. This evidence concerns the gene MKI67 and neoplasm.