Two HNSCC xenograft models, SCC4 and SAS models of 204~209 mm3 tumor volume, were then randomly distributed to five study subgroups: (1) PBS; (2) PDT (LCP siControl+PDT); +LCP Control siRNA, (3) LCP-Pyro PA+LCP EGFR siRNA, (4) PBS+light+LCP EGFR siRNA and (5) PDT (LCP-Pyro PA+light)+LCP EGFR siRNA. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.