On the other hand, temozolomide failed to decrease the phosphorylation level of p70S6K (Figure 4B) as well as Histone 3 (Ser10), which was shown in Figure 2C. Our data collectively show that high-dose finasteride restrains AKT/mTOR signaling, consequentially leading to the suppression of glioblastoma cell proliferation. The gene discussed is AKT1; the disease is glioblastoma.