CD4 and nasopharyngeal carcinoma: It has been reported that exosomes from EBV-immortalized lymphoblastoid cell lines (LCLs) and nasopharyngeal carcinoma (NPC) promote apoptosis or inhibit EBV-reactive CD4+ cells proliferation [90,200,201]; also, similar observations were reported with exosomes from NPC-xenografted mice and EBV-associated from nasopharyngeal carcinoma cases [202].