This mechanism reduces glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity, contributing to the overactivation of four classic hyperglycemia-induced metabolite pathways: (1) the polyol pathway, (2) the protein kinase C (PKC) pathway, (3) the Advanced Glycation End products (AGEs) pathway, and (4) the hexosamine pathway. This evidence concerns the gene GAPDH and Hyperglycemia.