On top of multiple activation by dual TLR agonists, synergistic immune stimulation of triple poly(I:C, pIC) (TLR 3 agonist for the reprograming of acute inflammatory state), R848 (TLR 7/8 agonist for inhibiting tumor-mediated T cell senescence), and macrophage inflammatory protein-3 alpha (MIP3α) (CCL20 for attracting cells expressing CCR6/CD196) in PLGA nanoparticles were also demonstrated [95]. This evidence concerns the gene CCR6 and neoplasm.