A combinatorial delivery of triple TLR agonists of MPLA (TLR 4 agonist), R848 (TLR 7/8 agonist), and CpG 1826 (TLR 9 agonist) using complement C3-liposomes also enhanced monocyte activation, up-regulated the inflammatory cytokines gene expression (e.g., IRF7, IP-10, IL-1b, IL-6, IL-12, and TNF-α) in myeloid cells, and reduced in vivo murine tumor growth. Here, C3 is linked to neoplasm.