The coexistence of the NUP98-NSD1 and the FLT3-UT3 mutation in leukemic cells exhibited a high sensitivity towards the FLT3 inhibitor, which was indicated by the aberrant FLT3 signaling in NUP98-NSD1-positive AML patients [80,81]. The gene discussed is FLT3; the disease is acute myeloid leukemia.