The finding that the P.R.R. of atrial fibrillation and arrhythmias as well as the muscular weakness and rhabdomyolysis are improved using multiple correlation equations supports the notion that multiple mechanisms, including KIR6.2-SUR2A channel blocking action, participate in this A.D.R. The contribution of the KIR6.1-SUR2B channel by ZOL to the atrial fibrillation and arrhythmias/hypertension is also supported by our multiple correlation analysis. The gene discussed is KCNJ8; the disease is hypertensive disorder.