Lambiase et al. compared neuropeptides in tear fluid in 19 DED patients (Sjögren’s DED, n = 5 patients; non-Sjögren’s DED, n = 10 patients; and ocular cicatricial pemphigoid, n = 4 patients) and 12 controls and reported decreased CGRP and NPY levels and increased NGF levels in the DED patients [233]. This evidence concerns the gene NPY and mucous membrane pemphigoid.