Bertani et al. (2020) [87] associated the presence of active ulcers (classified by MES) at baseline (prior to anti-TNF treatment) with higher NLR compared to those without active ulcers (p = 0.002) and reported a baseline NLR cutpoint at 2.06 could predict mucosal healing (MES ≤ 1) following 54 weeks of treatment with biologics (60% sensitivity, 79% specificity). Here, TNF is linked to ulcer disease.