Although the populations investigated differed among our studies with regards to the median eGFR (49 versus 23 mL/min/1.73 m2) and the prevalent stages of CKD (circa 90% CKD G3 versus 100% CKD G4 and G5), they could both demonstrate higher cutoff values of hs-cTnT and a high diagnostic accuracy. The gene discussed is TNNT2; the disease is chronic kidney disease.