To the best of our knowledge, this is the first study to investigate the diagnostic accuracy of hs-cTnT for the diagnosis of NSTE-ACS requiring revascularization in a considerable cohort of patients with severe CKD (eGFR < 30 mL/min/1.73 m2), including patients with CKD G5D. The gene discussed is TNNT2; the disease is chronic kidney disease.