AKT1 and cancer: Another finding is that one of the most relevant mechanisms of action of lncRNAs observed in this review are through ceRNAs (e.g., MALAT-1, PAGBC, LINC00152, MINCR, PAGBC, and PVT1), which is consistent with the mechanisms that can be described for lncRNAs that are upregulated in GBC, suggesting that lncRNAs act mainly as “sponging” against miRNAs, maintaining stability of oncogenic mRNAs and mainly inducing the activation of relevant signaling pathways widely described in cancer, such as PI3K/Akt, Wnt-β-catenin and MAPK.