Women with endometriosis also have significantly higher levels of serum markers of endothelial inflammation and activation, including the vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin, vascular endothelial growth factor, von Willebrand factor, and ristocetin cofactor, reflecting an early development of atherosclerosis [31]. The gene discussed is ICAM1; the disease is endometriosis.