HIF1A and neoplasm: Chronic hypoxia developed within tumor microenvironment may activate hypoxia inducible factor 1 (HIF-1) and NF-κB, inducing proliferation and stimulation of angiogenesis, inhibition of apoptosis, and activation of regulatory proteins associated with various cascades such as: MAPK, PI3K, tyrosine kinases, ion channels, and receptors connected to protein G. RAGE, similarly to TLRs and P2X7, is activated by hypoxia factor HIF-1α which also induces activation of NF-κB within activated B cells and expression of genes coding for proinflammatory cytokines [118,119].