ADCY2 and congestive heart failure: The discovery sample of patients in the E5103 trial used a binary analysis of congestive heart failure in 68 cases vs 987 controls, yielding nine variants associated at p < 10−5 with increased risk of congestive heart failure (HR = 2.1–2.7) from which they selected two variants (an intronic variant rs6883259 in ADCY2 and an intergenic variant on chromosome 15, rs28714259) for replication in a second sample of 47 cases and 883 controls from the E1199 trial.