No correlation between baseline symptoms severity scores measured using HDRS-17 and YMRS, and protein levels was discovered in MDD group (BDNF p= 0.54; proBDNF p = 0.23; mBDNF p = 0.31; rBDNF p = 0.08; EGF p = 0.6; MIF p = 0.54; SCF p = 0.92) as well as BD group (BDNF p= 0.22; proBDNF p = 0.12; mBDNF p = 0.13; rBDNF p = 0.09; EGF p = 0.34; MIF p = 0.73; SCF p = 0.53). This evidence concerns the gene BDNF and major depressive disorder.