Obesity also favors a deleterious adipocytokine pattern [68,69] characterized by the overproduction of angiotensinogen and angiotensin II as well as the upregulation of pro-inflammatory cytokines such as interleukin-6, C-reactive protein, and tumor necrosis factor-α. The gene discussed is AGT; the disease is obesity due to melanocortin 4 receptor deficiency.