It was further highlighted that by inhibiting HPGDS, we saw a 2-fold increase in hind limb grip strength, muscle protected from damage (20% decrease in damaged muscle fibers), lowered muscle fibrosis, and reduced CK-MM plasma levels (~50%) in the mdx PK007-treated group, suggesting that blocking HPGDS could provide an alternative therapeutic option in treating DMD. Here, CKM is linked to Duchenne muscular dystrophy.