According to the data from Ding and colleagues, the miR-520/372/373 families can target the 3′-UTR of SPOP (speckle-type POZ protein) which up-regulated in over 90% of renal cell carcinoma (RCC) and suppress the SPOP protein expression, thus leading to elevation of PTEN and DUSP7 levels and suppressing the progression of RCC in vitro and in vivo [94]. This evidence concerns the gene SPOP and hereditary clear cell renal cell carcinoma.