In summary, the ATM/ZEB1/USP7/CHK1, miR-200c/LINC02582/USP7/CHK1, USP7/PHF8, UCHL3/RAD51, USP52/ASF1A, and UCHL1/HIF-1 signaling axis are potential targets to improve the radiosensitivity of breast cancer. Here, PHF8 is linked to breast cancer.